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Abstract
Skeletal muscle injuries are one of the most frequently occurring injuries in sports medicine. Although these injuries are capable of healing, incomplete functional recovery often occurs due to excessive scar tissue formation. Suramin enhances muscle healing by both stimulating muscle regeneration and preventing fibrosis in lacerated skeletal muscle. Controlled laboratory study. In vivo: a single concentration of suramin was injected in the gastrocenimus muscle of mice at variable timing after muscle laceration injury. Muscle regeneration and scar tissue formation were evaluated by histologic and immunohistochemical analysis. Suramin treatment significantly promoted muscle regeneration, decreased fibrosis formation when introduced after laceration injury. Intramuscular injection of suramin after a laceration injury in a multiple dose manner improved overall skeletal muscle healing in comparison to single dose administration