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Abstract
Cognitive impairment is a common concomitant of multiple sclerosis (MS) at both the earlier and later stages of the disease. Objective: to study the pattern of cognitive impairment in various types of MS and its correlation to the results of conventional MRI (c MRI) and diffusion tensor MRI (DTMRI) of the brain. Results: a significant difference was found between cases and control in most of cognitive function tests. Significant difference was found between RRMS & SPMS in cognitive function test and DTMRI brain results (for corpus callosum and temporal lobe) being severe in SPMS patients. Significant difference was found between RRMS and SPMS in c MRI results as regards to brain atrophy being severe in SPMS patients. Conclusion: cognitive dysfunction and brain atrophy occurs early in MS. Cognitive dysfunction was more severe in SPMS than in RRMS patients. DTI brain of NAWM was correlated with cognitive dysfunction in MS especially in regions of corpus callosum, temporal & prefrontal lobes