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Abstract
Background: Sickle cell disease (SCD) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-{uF061}) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms and laboratory data in children with SCD. Results: In the present work, TNFÜ-AA genotype and the mutant A allele were higher in both groups of SCD patients compared to control group. But there was no significant difference detected between steady state and crisis patients regarding TNFÜ-AA genotype or TNFÜ-A allele. As regards IL-8; IL-8 TT genotype and mutant T allele were significantly higher in both groups of SCD patients compared to control group. There was no significant difference detected between steady state and crisis patients regarding IL-8 TT genotype or IL-8 T allele. Conclusion: from these results we can conclude that the presence of TNF-Ü ’’-308 G>A” and IL-8 ”-251 A>T” polymorphisms is associated with increased risk of morbidity in SCD, but is not associated with increased disease severity