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Abstract
Background: Multiple sclerosis (MS) is the quintessential neurologic disorder from which to understand the principles of afferent and efferent neuro-ophthalmology. The popularity of eye movements as an experimental tool arises, in part, because they can be conveniently and accurately measured and analyzed, but also because much is known concerning their neural substrate. It is therefore, no surprise, that eye movements have been commonly applied to better understand the visual and motor disorders in patients with MS. Objectives: The rationale of this study is to demonstrate the vast ocular motor abnormalities that occur in this disease using Videonystagmography as our tool of description and determine the relationship with EDSS, MRI findings. Results: The eye-movement disorders most commonly noted are saccadic dysmetria, followed by gaze-evoked nystagmus, and then pendular nystagmus. They are caused by disease affecting the brain stem and cerebellar circuits. Reduced pursuit gain and saccadic pursuit were also noted. A strong Colleration between Brainstem and Cerebellar MRI lesions and the affection of the ocular motor system were well noted. High EDSS score was well collerated with abnormal ocular motor tests findings. Conclusion: Oculor motor system tests are more sensitive than conventional clinical examinations in identifying abnormalities in MS as compared to the control group