الفهرس Only 14 pages are availabe for public view
 |  | from | 105 |  |  |
| | | from | 105 | | |
Abstract
Background: CTCL are non-Hodgkin lymphomas characterized by a dominant skin- homing T-cell clone with different clinical presentations. MF is the most common subtype. It includes hypopigmented, hyperpigmented, ichthyosiform, pityriasis lichenoides-like, granulomatous, folliculotropic, bullous, palmo-plantar, pagetoid reticulosis and granulomatous slack skin, several gaps are still present in our understanding of the pathogenesis. MiRNAs are small noncoding RNA molecules involved in the regulation of various physiological and pathological processes. Altered expression of different miRNAs has been observed in both solid tumors and haematological malignancies. MiRNA-93, one of members of miR-17{u2013}92 cluster, which role was proved in enhanced cell survival, promoted sphere formation and augmented tumor growth. Objectives: The aim of this study is to evaluate the expression level of miRNA-93 in early stage MF