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Abstract
Background: Acquired Melanocytic Nevi (AMN) have been reported to undergo morphological and dermoscopic changes following exposure to NB-UVB radiation. Objectives: To study the clinical, dermoscopic and immunohistochemical changes in AMN exposed to NB-UVB radiation. Patients and Methods: 40 patients diagnosed with different dermatological conditions were enrolled in the study. Three sessions of suberythemogenic NB-UVB per week were delivered for a total of 30 sessions. For each patient a minimum of 2 nevi were selected. One nevus was surgically removed prior to sessions as control, for the other nevus/nevi dermoscopic images were captured before and after NB-UVB sessions. The images were evaluated for morphological and dermoscopic changes. At the end of the irradiation cycle another nevus was surgically removed. Immunohistochemical assessment of Ki67 (marker of proliferation) and Melan A (marker of melanogenesis) were done for the biopsy specimens