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Abstract Neurogenesis is defined as the series of developmental stages that leads to the formation of a mature, functionally integrated neuron from the division of a neural stem or progenitor cell. It was considered to be limited to embryonic stages. Later on, it was discovered to persist in two neurogenic niches of the adult mammalian brain: the subgranular zone (SGZ) of the dentate gyrus of the hippocampus and the subventricular zone (SVZ) of lateral ventricles. These regions are known to generate new neurons that partly integrate into the pre-existing networks of the hippocampus and the olfactory bulb (OB) respectively. New neurons differentiate from SGZ in a population of excitatory glutamatergic projection neurons, while SVZ progenitors give rise to diversified subpopulations of inhibitory GABAergic interneurons in the OB. In both the adult hippocampus and the SVZ-OB, the neurogenic process is thought to be tightly controlled by intrinsic and extrinsic factors. |