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العنوان
Analysis of COUP-TFI expression and function in dentate gyrus of hippocampus in adult mice /
المؤلف
Taha, Doaa Marei Abdallah.
هيئة الاعداد
باحث / Doaa Marei Abdallah Taha
مشرف / Hassan A.Abdel-latif
مشرف / Silvia De Marchis
مشرف / Sherine Abdel Salam
الموضوع
COUP.
تاريخ النشر
2015.
عدد الصفحات
93 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأعصاب
تاريخ الإجازة
1/1/2015
مكان الإجازة
جامعة الاسكندريه - كلية العلوم - Zoology
الفهرس
Only 14 pages are availabe for public view

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Abstract

Neurogenesis is defined as the series of developmental stages that leads to the formation of a mature, functionally integrated neuron from the division of a neural stem or progenitor cell. It was considered to be limited to embryonic stages. Later on, it was discovered to persist in two neurogenic niches of the adult mammalian brain: the subgranular zone (SGZ) of the dentate gyrus of the hippocampus and the subventricular zone (SVZ) of lateral ventricles. These regions are known to generate new neurons that partly integrate into the pre-existing networks of the hippocampus and the olfactory bulb (OB) respectively.
New neurons differentiate from SGZ in a population of excitatory glutamatergic projection neurons, while SVZ progenitors give rise to diversified subpopulations of inhibitory GABAergic interneurons in the OB. In both the adult hippocampus and the SVZ-OB, the neurogenic process is thought to be tightly controlled by intrinsic and extrinsic factors.