الفهرس 
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Abstract
UC is a chronic inflammatory disease with lifelong relapsing and remitting course. Assessing the activity of the illness and predicting treatment outcomes in UC patients is vital. The evaluation is based on clinical, serological, and endoscopic results. Clinical and serological tests, which are non-invasive, inexpensive, and easy to use in clinical practice, are usually used to support the relative degree of inflammation and control the progression of the disease. The previous study aimed to evaluate trefoil factor 3 and hematological parameters (Neutrophil to Lymphocyte ratio (NLR)) (Platelet to Lymphocyte ratio (PLR)) in prediction of ulcerative colitis activity. The patients were divided into: group I: Fifty adult UC patients are subdivided into (group 1A) active UC and (group 1B) inactive UC according to clinical condition, laboratory investigations, and endoscopic evaluation with biopsy examination. group II: Twenty-five patients with normal colonoscopic examination. ❖ Inclusion criteria: All patients were adults, patients with a confirmed diagnosis of UC confirmed by a clinical, endoscopic, and histological workup. ❖ Exclusion criteria: Patients known to have: • History of colorectal surgery • Pregnancy • Colorectal cancer or colon polyp • Indeterminate colitis • Infectious colitis • Primary Immunodeficiency. • Diabetic patient • Neurological disorders • chronic kidney disease All patients were subjected to: • Full history taking. • Full clinical examination. • Routine laboratory investigations including: o Complete blood count (CBC). o ESR. o C reactive protein (CRP). o Stool analysis. o Liver function tests. o Renal function tests. o Faecal calprotectin • Specific laboratory investigation: o Serum Trefoil factor3 estimation using ELISA technique. o Neutrophil to lymphocyte ratio (NLR) o Platelet to lymphocyte ratio (PLR). The main findings can be summarized as follows: • Hb level showed statistically significant decrease between (group 1& group 2). Also, there was statistically significant decrease between (group 1A & group 1B) (p-value<0.001). • According to platelet count, there was statistically significant increase between (group 1 & group 2) (p - value <0.001). However, there was statistically significant increase between (group 1A & group 1B) (p-value <0.001). • TLC was reported statistically significant difference between (group1& group2), (group1A &group 2) (pvalue< 0.001) and insignificant difference between (group 1A& group1B) (p-value=0.413). • Regarding NLR there was statistically significant difference between (group1& group2) and insignificant difference between (group 1A& group 1B) (P-value =0.004) and insignificant difference between (group 1A& group1B) (p-value =0.610). The cutoff 1.418, (ROC) curve analysis in diagnosis UC from control group sensitivity 86%, specificity 56%, PPV 79.62%, NPV66.6%. • Regarding PLR there was statistically significant difference between (group1& group2) (pvalue= 0.002) with insignificant difference between (group 1A& group1B) (p-value=0.286). Regarding PLR for detection of UC patients active, remission and control. At cut off value of 102.125; area under the curve was 0.610, the sensitivity was 67%, specificity was 50%, positive predictive value (PPV) was 84.37%, and negative predictive value (NPV) was 27.77%. • FC showed a highly statistically significance increase between studied groups. there was significant increase between (group1A& group1B) and (group 1A& group2) (p-value<0.001). However, there was no significant difference between (group1B& group2) (p-value>0.05). • As regard TFF3, there was statistically significant between studied groups (group 1 and group 2) also, between (group 1A& group 1B), (group1A& group 2) p-value<0.001. However, there is no significant difference between group 1B and group2. The median value of TFF3 was 993.3 pg/ml in group 1A, 617 pg/ml in group 1B and 411 pg/ml in group 2. • TFF3 cut off level to predict activity of UC patients was 408.55 pg/ml, (AUC) was 0.905:95%CI, (0.819- 0.991). The sensitivity was 92.5% and specificity was 80%. • TFF3 was positively correlates with inflammatory markers (ESR and CRP), FC and endoscopic activity (p<0.001).