الفهرس 
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Abstract
The exaggerated immune response in severely ill COVID-19 patients entails the so-called cytokine storm. In this study, we investigated the relation between Soluble interleukin-2 receptor (sIL-2R), IL-6 and IL-10 in hospitalized patients with severe COVID-19 infection.
Methods: This single center cohort study was conducted on 250 severe COVID-19 patients. Chemiluminescence immunoassay method was used to measure levels of procalcitonin, ferritin, sIL-2R, IL6, and IL10.
Results: At the end of follow up, 102 patients died (40.8 %). Survivors had significantly lower levels of IL-2R [257.0 (219.3-373.0) versus 813.0 (647.5-990.0), U/ml p0.001], IL-6 [27.0 (19.0-41.0) versus 134.0 (75.0-235.5), μg/L p0.001] and IL-10 [18.0 (13.0-30.0) versus 106.5 (58.8-180.8), μg/L p0.001]. Correlation analysis identified significant positive correlation between IL-2R, IL-6 and IL-10 levels and almost all the inflammatory and coagulation parameters including CRP, LDH, procalcitonin, ferritin, D-dimer and fibrinogen.
Conclusion: Elevated levels of sIL-2R, IL-6 and IL-10 are associated with greater risk of mortality in Covid-19 patients.