الفهرس 
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Abstract
Aim: This study evaluates the clinical and microbiological effects of HYBENX oral tissue decontaminant gel (HOTD) as an adjunct to mechanical therapy in moderate chronic Periodontitis patients and comparing this effect with scaling and root planning (SRP) only. Materials and Methods: Forty moderate chronic periodontitis patients (16 females, 24 males, age: from 30 to 60 years old) were involved in the study. They were divided into 2 groups randomly. First group composed of 20 patients who received SRP associated with the subgingival application of HOTD (EPIEN Medical, Inc. St. Paul, MN, USA) and second group composed of 20 patients who received SRP only. Local drug delivery was applied once weekly for six weeks. All patients were evaluated clinically by measuring periodontal parameters (plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL)) , and microbiologically by culturing plaque samples anaerobically for detection of total bacterial count, Porphyromonas gingivalis and Prevotella intermedia counts at baseline and six weeks after periodontal treatment. Results: at baseline, there was no significant difference between the 2 groups regarding clinical parameters (PI, GI, PPD, CAL), and microbiological parameters (total bacterial count, p.gingivalis and p.intermedia count). Six weeks after treatment, clinical and microbiological parameters showed a significant reduction in both test and control groups. However, by comparing between groups after treatment, the test group showed a significant difference in clinical measures (PI, GI, and PPD) and the microbiological parameters (total bacterial count, p.gingivalis and p.intermedia count) versus the control group. Conclusion: HOTD gel, used as local drug delivery, is an effective adjunctive treatment for chronic periodontitis patients.