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Abstract Zinc oxide nanoparticles (ZnO NPs) are applied in nutrition and personal care products, such as cosmetics and sunscreen. Although, NPs are important, upon their uses they might have some toxic effects. These effects depend on their concentrations and exposure duration. The present study focused on the effect of intraperitoneal (IP) injection of ZnO NPs on the new born and adult male Sprague Dawley rats and evaluating the histopathological alterations of the cerebellum and liver, in addition to study the ameliorative role of Ethylenediaminetetraacetic acid (EDTA) against ZnO NPs toxicity. The study examined the effect of a single dose and repeated daily dose for 7 and 21 of ZnO NPs on new born male (NBM) and adult male (ADM) rats. And evaluating the ameliorative effect of treatment with EDTA for 7 consecutive days after injection with zinc oxide nanoparticles in all the experiments |