الفهرس 
Overview of HypercholesterolemiaOnly 14 pages are availabe for public view
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Abstract
The main target of this study was evaluate the effect of two concentration 15% and 30% of dry and germinated oat, barley and brown rice consumption for 6 weeks on hypercholesterolemic rats. Eighty four male albino rats weighing 200 -220 g were divided into fourteen groups (6 rats in each group). First group fed on basal diet (negative control group). The second group fed on hypercholesterolemic diet (HCD) (1% cholesterol+16% saturated fat and 0.5% colic acid) positive control. Groups (3, 4, 5, and 6) rats fed on HCD containing 15%, 30% whole dry oat and 15%, 30% germinated oat group (7, 8, 9 and 10) rats fed on HCD containing 15%, 30% dry barley and 15%, 30% germinated barley. Groups (11, 12, 13 and 14) rats fed on HCD containing 15%, 30% dry brown rice and 15%, 30% germinated brown rice. At the end of the experimental period body weight gain and organs weight was estimated and serum collected to determine total cholesterol (TC), triglyceride (TG), aspartate aminotransferees (AST), alanine aminotransaminase (ALT), creatinine, uric acid, urea and glutathione reduced (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxides (GPx), chemical composition analysis. The results demonstrated that germinated oat contained highest fiber (14.35±2.03 g/100g) while, germinated barley contained lowest levels of fiber (6.86±0.96 g/100g). Also, HCD caused a significantly increase in TC, TG, low density lipoprotein cholesterol (LDL- C), very low density lipoprotein cholesterol (VLDL-C), Atherogenic index (AI) LDL/HDL ratio, AST, ALT and kidney function, Furthermore, it caused a significantly decrease in HDL, HTR, GSH, CAT, SOD and GPx (29.13±0.37 mg/dl, 28.59±1.84, 1.45±0.14IU/L, 1405.0±58.67IU/L, 61.50±3.08UI/L and 188.66±2.42 IU.L) respectively. The rats received dry oat, dry barley and dry brown rice with high concentration (30%) was the most effective to reduction of TC and LDL-C than dry 15% and germinated 15% levels of that grains. While, germinated oat, germinated barley and germinated brown rice 30% revealed non- significant effect on TC and LDL-C levels, although it has more effective to raise antioxidant enzymes a activity. Furthermore, dry oat 15%, dry barley 30% and germinated brown rice 15% were the most effective to TG decreases (49.25±5.23, 48.50±3.38 and 49.25±5.81 mg/dl) respectively. All treatments revealed a significantly decrement of AI, ALT, AST, creatinine, uric acid. In addition, dry oat 15% and 30%, dry barley 30%, germinated barley 15% and germinated brown rice 15% were the most impact to improve VLDL-C. Conclusion: addition of whole dry and germinated oat, barley and brown rice to HCD for 6 weeks has potential effects to reduced serum cholesterol levels, LDL-C and VLDL-C. Oats have hypo-cholesterolemic effect more than barley and brown rice. The high concentration of dry grains and low concentration of germinated grains had more effective to reduced lipid profile. While, the low concentration of germinated oat more impact than high concentration of germinated grains.
Key words: Hypercholesterolemia, Barley, Oat, Brown rice, -glucan, Germination, Antioxidant enzymes, Lipid profile