الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
In conclusion, we have synthesized new hybrid molecules containing hydrazine moiety as illustrated in part 1, which proved that thioamide Schiff base ligand and its complexes
{M(II)ATHSB; M = Mn(II) , Cu(II) , Zn(II)} have been succefully synthesized. The coordination modes, stoichiometry, geometery, thermal stability, and morphology of M(II)complexes were deduced based upon the outputs of different physicochemical, spectroscopic and microscopic techniques. The comparative in-vitro anticancer studies revealed that all complexes are more cytotoxic than the parent ligands against human cancer cell lines (liver carcinoma (HepG2), colon carcinoma (HCT116), whereas, they exhibited lower toxicity as compared to the free ligand against normal liver cells (HL7702). Complex Zn(II)ATHSB seems to be a superlative candidate as it the most cytotoxic one against (HepG2) concomitantly in lowest toxicity toward the normal human liver cells (HL7702), thus may offering a probable alternative to conventional chemotherapeutic agents for cancer therapy.
In part 2, Mn(II), Cu(II) and Zn(II) complexes of azo-dye Schiff base ligand have been prepared by reaction of ligand with metal(II) chlorides in 1:1 molar ratio. The coordination profiles of HL with M(II) ions, stoichiometry, and stereochemistry of metal complexes were investigated based upon various physicochemical and spectroscopic techniques. The thermal stability and surface morphological features of the free ligand and its coordination compounds have been studied using TGA, DTA, and SEM analysis. The comparative in-vitro anticancer studies revealed that all complexes are more cytotoxic than the parent ligands against human cancer cell lines MCF- 7 , whereas, they exhibited lower toxicity as compared to the free ligand against normal cells; signifying the importance of these complexes as new potential candidates to develop and explore novel chemotherapeutic agents in the field of cancer therapy. Particularly Cu(II)2-THSB seems to be a superlative candidate as it the most cytotoxic one against MCF-7 concomitantly in lowest toxicity toward the normal human cells MCF-7, thus may offering a probable alternative to conventional chemotherapeutic agents.