الفهرس 
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Abstract
In the last few years, the market for sweeteners has grown tremendously.
Aspartame is a common artificial sweetener that is thought to be dangerous. On
the other hand, stevioside is a plant that includes sugar and was assumed to be a
natural alternative to artificial sweeteners. Objectives: The objective of this
study was to determine whether aspartame or stevioside affected
biochemical,sero-biochemical, and immunohistochemical changes in adult rats
following six weeks. Material and Methods: Forty-eight rats were used and
divided into three groups: group I: the control group, group II: rats received
aspartame (75 mg/kgday), group III:rats received stevia (45 mg/kgday). All
medications were given orally for 6 weeks. Lipid Peroxidation product (MDA);
liver glutathione (GSH); nitric oxide (NO);Liver Superoxidase dismutase
activity(SOD); catalase (CAT), Low-density lipoprotein (LDL) ; very low
lipoprotein (VLDL) ;the cholesterol in the HDL;Alanine Aminotransferase
(ALT), and Aspartate Aminotransferase (AST); Creatinine, Urea, Total
proteins were performed on blood and tissue specimens. Results: Aspartame
group showed an increase in levels than the control group and stevioside
treated showed a decrease in levels than the control group aspartame had more
harmful effects than stevia. Conclusion: Stevioside was less harmful than
aspartame.