الفهرس 
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Abstract
Psoriasis is a chronic inflammatory dermatological disorder manifested mainly by multiple itchy, scaly, erythematous plaques distributed at any site in the body especially elbows and knees.
It is a multifactorial disorder showing hyper proliferation of the keratinocytes in the epidermis, with an increase in the epidermal cell turnover rate due to underlying Environmental, genetic, and immunologic factors.
Toll like receptors (TLRs) are a family of pattern recognition receptors that play a central role in the innate immune response. These receptors are expressed on a wide variety of immune and non-immune cells, and play an important role in most inflammatory and autoimmune diseases.
Toll like receptor 2 is one of most important toll like receptors that plays an important role in many systemic and dermatological disorders.
Toll like receptor 2 single nucleotide gene polymorphism is involved in pathogenesis of multiple dermatological disorders as acne vulgaris, pemphigus disorders, rosacea and some malignant skin diseases.
This current work was done to explain the role of toll like receptor 2 single nucleotide gene polymorphism in the pathogenesis of psoriasis vulgaris. The study included 30 psoriatic patients and 30 healthy volunteers serving as a control group.
The results of the present study showed noteworthy difference between cases and controls as regard expression of toll like receptor 2 single nucleotide gene polymorphism. Finally, the present study fulfilled that toll like receptor 2 single nucleotide gene polymorphism may have an essential role in the pathogenesis of psoriasis.