الفهرس 
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Abstract
Diabetic retinopathy (DR) refers to a microvascular problem that results because of DM for a long duration, resulting in vision-threatening destruction of the retinal layer, finally causing loss of vision. It’s the commonest reason for marked visual loss in adult patients of working age group in the western world. Early determination as well as the interventions in the proper time are crucial to prevent visual loss because of DR.
Uncontrolled DM may result in several eye diseases such as cataract, glaucoma, eye surface diseases, recurrent styes, non-arteritic anterior ischemic optic neuropathy, DM papillopathy, and DR.
Out of which DR represents the commonest and aggressive eye complication. Weak glycemic control, uncontrolled HTN, dyslipidemia, nephropathy, male gender, and increased body weight are accompanied by aggravation of DR.
The objective of this study is to examine the vitreoretinal interface alterations at neovascularization sites in patients with PDR by SD-OCT before and after PRP.
Our study was performed on 30 eyes undergoing PRP for treatment of PDR patients.
The study was conducted as a single-centre, prospective interventional case series study.
A total of 30 eyes having PDR in 15 cases were incorporated in our study. The age of studied cases was between 39 and 64 years.
The most frequent DM type was type I (73.3%). The duration of DM ranged from 13- 35 years.
The mean HbA1C level was 9.253%± 1.88.
The mean BCVA measured in the 30 studied eye was 0.317± 0.17 and ranged from 0.05 to 0.70.
The studied eyes were divided based on the rise of posterior hyaloid in the SD-OCT scans prior the PRP therapy into:
1. Alterations in SD-OCT scans in eyes having detached posterior hyaloid face in the pretreated SD-OCT scans (21 eyes that represent 70% of included eyes) are:
a. Progression of PVD was detected in 18 eyes that represent 60% of the included eyes with:
i. Severe aggravation of the RT: this was determined in 11 (36.7%) of included eyes.
ii. Relieved pre-existed RT caused by separation of stickiness between the posterior hyaloid and the inner surface of the retina was detected in two (6.7%) eyes.
iii. Stable retinal traction was observed in five (16.7%) eyes.
b. No visible alteration at the vitreoretinal interface has been reported in three (10%) eyes.
2. SD-OCT alterations in eyes showing no visible posterior hyaloid face in the pretreated SD-OCT scans (9 eyes that represent 30% of included eyes) included:
a. Regression of new vessels has been detected in 7 (23.3%) eyes.
b. Post laser detachment of prior attached posterior hyaloid has been observed in two eyes (6.7%).
In 30 eyes with PDR, NVD was detected in 7 (23.3%) eyes by Fluorescein Angiography and neovascularization elsewhere (NVE) was detected in 23 (76.7%) eyes by Fluorescein Angiography.