الفهرس 
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Abstract
Prostate cancer is the most commonly diagnosed non-skin cancer in men in the world with mortality rates only second to lung cancer.
In the normal prostate, there is a balance between the of cell proliferation and cells undergo apoptosis resulting in maintenance of the size of the gland. AR is one of the most important genes that has been implicated in PCa development and progression. Androgens regulate the proliferation rates of epithelial cells, the predominant cell type involved in adenocarcinoma, so increased androgen levels or AR activity could result in uncontrolled proliferation and cancer development.
It was a cross sectional analytic study to assess the expression patterns of AR in prostatic adenocarcinoma in correlation with the histopathological findings in order to evaluate its role as prognostic marker or possible therapeutic target.
The study sample included 35 specimens sampled b TRUP and TRUS diagnosed as prostatic adenocarcinoma and archived in pathology laboratory, Suez Canal University Hospital during the period from January 2011 to December 2018.
Out of the studied thirty-five specimens, specimens divided into 3 groups : <50 years, 50-70 years & >70 years.
19 specimens (54.3%) were at age group (>70),13 specimens (37.1%) were at age group (40-70) and 3 specimenms (8.6%) were at age group (<40 ).
Histopathological examination of the examined specimens showed