الفهرس 
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Abstract
OA is the most frequent chronic musculoskeletal disease. The joint pain is usually the chief complaint of symptomatic OA which leads patients to seek medical services. Central sensitization and maladaptive changes in endogenous pain modulation play a significant role in shaping clinical pain symptoms in OA patients.
At present, there is a great interest in the science for measures capable of assessing pain mechanisms like CPM as there is evidence suggesting that they act as important predictors of chronic pain and treatment response.
Our study aimed to evaluate the role of CPM as a predictor of central sensitization in OA patients with chronic pain.
We enrolled in our study, fifty OA patients, and fifty healthy controls. Both groups were matched for both age and gender.
Complete history and clinical examination were done in all studied subjects. Each subject in both groups was evaluated by subjective measures as VAS for pain at rest and after activity , WOMAC questionnaire for pain, stiffness, and physical function, PDQ for classifying OA pain into nociceptive or neuropathic and also CSI for identifying patients who have symptoms that may be related to central sensitization and quantify the severity of these symptoms. Also, we evaluated the subjects by objective measures as PPT, EPT and CPM.
We found that VAS means of knee pain at rest and activity were higher in OA than in the control group with statistical significance. Regarding WOMAC questionnaire for the assessment of OA severity, we found a decrease in physical function, an increase in stiffness, and pain severity in OA patients versus control with statistical significance. Both VAS and WOMAC are subjective indicators of peripheral sensitization.