الفهرس | Only 14 pages are availabe for public view |
Abstract Cardiac toxicity is defined as the toxicity that affects the heart either by a direct effect of the drug on the heart, the indirect effect due to the enhancement of hemodynamic flow alterations or due to thrombotic events. Cardio toxicity has an increasing relevance as a result of the global improvement in cancer management, which leads to better survival and, therefore, adverse effects of treatments have significant consequences on patient outcome. Doxorubicin (DOX) is a cytotoxic agent that comes under the class of anthracycline antibiotics. DOX is isolated from the culture of Streptomyces, and displays a broad spectrum activity against many different tumor types, therefore remains one of the pillars of oncological treatment. The management of cardiovascular disease before and during cancer antineoplastic treatment is essential to reduce morbidity and mortality in cancer patients. Extensive studies have focused on identifying the methods or drugs capable of reducing this cardiotoxicity. One of these approaches is the use of plant products that play an important role in health care delivery as therapeutic remedies in the world, especially in developing countries. Medicinal plants are rich in bio-resources of drugs and these chemical compounds play a definite physiological action in the human body system and have always been resources of traditional and even modern medicines, because they have effective in treating diseases |