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العنوان
Therapeutic Role of Drug- Loaded Zinc Oxide Nanoparticles Composites for Cancer
/ Treatment in a Tumor Mice Model
المؤلف
Mohamed, Asmaa Abdel Ghany Ibrahim.
هيئة الاعداد
باحث / اسماء عبد الغنى ابراهيم محمد منصور
مشرف / غادة عبد الحميد طبل
مشرف / سمية زكى عبد الحليم
مشرف / سها جمعة رمضان
الموضوع
Zoology.
تاريخ النشر
2023.
عدد الصفحات
169 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
17/9/2023
مكان الإجازة
جامعة طنطا - كلية العلوم * - علم الحيوان
الفهرس
Only 14 pages are availabe for public view

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from 198

Abstract

Cancer tends to remain the major cause of fatalities worldwide. For decades, scientists have been hoping to find a promising cure for the said menace. Current clinical therapy for cancer includes chemotherapy, surgery, radiotherapy, and less commonly gene therapy and hyperthermia (HT), amongst others. However, various associated
side effects undermine their use, for example, cardiotoxicity and myelosuppression in chemotherapy; alongside infection, bleeding, or
irritation in radiotherapy and surgery respectively. Chemotherapy is the most preferred treatment for various types
of cancers; however, the low therapeutic efficacy and high toxicity are major drawbacks. Drug resistance exhibited by the tumor cells is also major challenge for effective treatment of cancer. Nowadays, there are many anticancer drugs applied for cancer treatment such as Doxorubicin, a well-known anticancer drug for treatment of several types of cancers including breast cancer. The major drawbacks are the side effects, cellular uptake and drug resistance of cancer cells. Chemotherapeutic drugs are generally spread out evenly within the
body; as a result, they have effect not only on cancer cells but also on healthy cells. Therefore, drug delivery system (DDSs) have been designed to increase the influence of chemotherapy and decrease toxicity by not only providing increment of drug accumulation in tumor
site but also lowering quantity.