الفهرس | Only 14 pages are availabe for public view |
Abstract Cancer tends to remain the major cause of fatalities worldwide. For decades, scientists have been hoping to find a promising cure for the said menace. Current clinical therapy for cancer includes chemotherapy, surgery, radiotherapy, and less commonly gene therapy and hyperthermia (HT), amongst others. However, various associated side effects undermine their use, for example, cardiotoxicity and myelosuppression in chemotherapy; alongside infection, bleeding, or irritation in radiotherapy and surgery respectively. Chemotherapy is the most preferred treatment for various types of cancers; however, the low therapeutic efficacy and high toxicity are major drawbacks. Drug resistance exhibited by the tumor cells is also major challenge for effective treatment of cancer. Nowadays, there are many anticancer drugs applied for cancer treatment such as Doxorubicin, a well-known anticancer drug for treatment of several types of cancers including breast cancer. The major drawbacks are the side effects, cellular uptake and drug resistance of cancer cells. Chemotherapeutic drugs are generally spread out evenly within the body; as a result, they have effect not only on cancer cells but also on healthy cells. Therefore, drug delivery system (DDSs) have been designed to increase the influence of chemotherapy and decrease toxicity by not only providing increment of drug accumulation in tumor site but also lowering quantity. |