الفهرس 
Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusion
Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver and the sixth most common cancer in the world. Its incidence is increasing worldwide reaching half million cases each year.
Early diagnosis of HCC is very important to improve its prognosis. Nowadays surveillance of HCC in patients with chronic liver diseases is achieved by regular periodic ultrasonography and tumor marker tests .
The primary marker for HCC is AFP which is not secreted in all cases of HCC and may be normal in as many as 40% of patients with early HCC.
The Amphiregulin has been identified as one of the 10- gene signatures in close association with the occurrence of liver metastasis in colorectal cancer patients. The expression of AREG in normal livers is undetectable; however, it is induced during acute and chronic liver injury AREG is an early response growth factor during liver regeneration. It also contributes to the transformed phenotype of human hepatocellular carcinoma cells.
Aim of the work is biochemical study of amphiregulin protein in Hepatitis C virus patients.
This study involved 90 participants in 3 groups: group (1): Control group which is composed of 30 healthy subjects. group (2): Cirrhosis group which is composed of 30 patients with chronic liver disease (cirrhosis). group (3): HCC group which is composed of 30 patients with hepatocellular carcinoma on top of HCV-related liver cirrhosis.