الفهرس 
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Abstract
Behcet’s disease (BD) is a multisystemic disorder characterized by recurrent involvement of mucocutaneous (including recurrent aphthous stomatitis; RAS), ocular, intestinal, vascular, and/or nervous system organs. Previously, the positivity of “pathergy test”, which is one of the diagnostic examinations, was reported to be related to the possession of HLA-B51 gene in BD patients, even though the positivity is low and different from the countries. Here, instead of the ordinal pathergy test, we would like to propose the prick with self-saliva as a new diagnostic way for patients with RAS of BD based on the genetic intrinsic factors including HLA-B51 and extrinsic triggering factors. BD patients are considered to acquire the hypersensitivity against oral streptococci through the innate immune mechanism in the oral cavity.
The current study included 30 Behçet’s patients, 30 recurrent aphthous stomatitis (RAS) patients and 30 matched healthy controls.
During clinical examination oral ulceration was present in all Behçet’s disease and RAS patients (100.0%). While the genital ulceration was present in (90.0%) of Behçet’s disease and (6.7%) of RAS patients
As regards eye examination, anterior and posterior segment uveitis had been detected among (43.3%) and (40.0%) of Behçet’s disease patients. And it was absent among RAS patients and controls.
Our study demonstrated the diagnostic accuracy of skin prick test with self-saliva and pathergy test for discrimination between patients with Behçet’s disease and non Behçet’s disease participants. Among 30 Behçet’s patients, 11 (36.7%) reacted positive to saline in the pathergy test. The number of positive reacting patients increased to 16/30 (53.3%) in filtered self-saliva prick test and to 23/30 (76.7%) in neat self-saliva prick test.
Our study demonstrated that skin prick test with saliva showed a significantly higher sensitivity (96.7) and specificity (93.3) in diagnosis of Behçet’s disease.