الفهرس 
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Abstract
The recent emergence of nanosized porous metal-organic frameworks (nano MOFs) in the nanomedicine field has lately attracted a sufficient deal of interest owing to their versatile structure and high porosity. Particularly attractive is the mesoporous Zirconium based MOFs (NH2-UiO-66 stands for the University of Oslo), which has shown exceptional loading capacity of challenging biomolecules such as anticancer drugs, alongside their controlled release profile under physiological conditions and interesting imaging properties. Furthermore, Zr-based MOFs gather optimal stability towards hydrolysis and postsynthetic functionalization with low toxicity. However, prior to any medical applications, it is vital to explore its toxicity and biodistribution behaviour which are mainly affected by several factors including structure composition, surface engineering, degradability, etc. Thus, this Ph.D. work aims to fabricate and test a smart multifunctional nanosystem based on Zr-based Nano MOF with further postsynthetic modifications as a nanocarrier for the chemotherapeutic drugs to develop Drug delivery systems (DDSs) and its application in hepatic cancer therapy. The aim of this work was validated through full physicochemical characterization for the designed nanosystems alongside the evaluation of the nanosized MOF toxicity and their physiological barrier crossing from different administration routes (specifically, the in vitro biological assessments on hepatic cancer cell lines).