الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The process of discontinuing mechanical ventilation is a crucial and universally recognized component in the management of critically sick patients who are intubated and receiving mechanical ventilation. The process of weaning encompasses the comprehensive liberation of the patient from mechanical assistance and the removal of the endotracheal tube, while also considering pertinent aspects of final care.
The process of discontinuing mechanical ventilation necessitates the implementation of dynamic and collaborative decision-making strategies in order to mitigate complications and prevent any delays in the transition to extubation. Achieving effective collaboration in this context necessitates the establishment of open, extensive, and coordinated communication among the healthcare team, along with the establishment of shared goals. This collaborative approach is expected to yield enhanced quality of care, improved patient safety, and favorable discharge outcomes.
Hence, the problem of predicting the outcome of extubation and preventing the occurrence of extubation failure holds significant importance.
The objective of this study was to evaluate the association between cardiac dysfunction and the risk of weaning failure from mechanical breathing, utilizing transthoracic echocardiography as a diagnostic tool.
The present investigation comprised a cohort of 90 individuals who had endotracheal intubation and mechanical ventilation for a duration exceeding 48 hours within the designated study timeframe. The participants for this study were selected from the Anaesthesia and Intensive Care Department at Minia University Hospitals.
Following the acquisition of written informed consent from the participants or their respective relatives, a comprehensive evaluation was conducted on each individual. This evaluation encompassed a thorough investigation of their medical history, a clinical assessment, and an evaluation of their respiratory parameters.
Transthoracic echocardiography was conducted on all instances, and further follow-up was conducted to ascertain the outcome of the weaning procedure, namely whether it was successful or not.
The findings of the present study revealed that: • The prevalence of weaning failure was 42.2%, whereas weaning success was observed in the remaining 57.8% of cases. • The average age of individuals experiencing weaning failure was significantly higher when compared to those who achieved successful weaning. • No significant differences were observed in terms of gender distribution and body mass index (BMI) between individuals with weaning failure and those with weaning success.
The prevalence of various comorbidities did not exhibit a statistically significant difference between cases with weaning failure and weaning success, with the exception of chronic obstructive pulmonary disease (COPD), which was shown to be considerably higher in instances with failed weaning.
There was no statistically significant disparity observed in the indications of mechanical ventilation between the patients characterized by weaning failure and those characterized by weaning success.
The user’s text lacks academic style and content.The cases with weaning failure had a statistically significant prolongation in the duration of artificial breathing.
The instances with weaning failure exhibited significantly higher scores on the SOFA score and APACHE II, in comparison to the cases with weaning success.
The patients with weaning failure exhibited a statistically significant increase in mean heart rate compared to the instances with weaning success.
The user’s text lacks sufficient information to be rewritten in an academic manner.The patients with weaning failure exhibited a statistically significant decrease in mean oxygen saturation compared to the instances with weaning success.
The patients with weaning failure had statistically significant elevations in mean respiratory rate, positive end-expiratory pressure (PEEP), partial pressure of oxygen (PO2), and partial pressure of carbon dioxide (PCO2) as compared to the cases with weaning success.
The cases with weaning failure exhibited statistically significant reduced mean tidal volume and FIO2 compared to the cases with weaning success.
The instances with weaning failure had statistically significant increases in the mean E wave, A wave, and E/A ratio when compared to the cases with weaning success.
The cases with weaning failure had statistically significant lower mean EF and e’ values compared to the instances with weaning success.