الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Primary malignant bone tumors are rare lesions. Before the 1970s, management routinely consisted of amputations or disarticulations, with dismal survival rates (10% to 20%). With the development of more effective chemotherapeutic agents and treatment protocols, in the 1970s and 1980s, survival rates improved, which allowed the focus of management to shift to limb preservation.
Currently, 80% to 85% of patients with primary malignant bone tumors involving the extremities (eg, osteosarcoma, Ewing’s sarcoma, and chondrosarcoma) can be treated safely with wide resection and limb preservation where the multimodality therapy has increased long-term survival rates of patients with chemotherapy-sensitive tumors to 60% to 70%.