الفهرس 
Non-Hodgkin’s LymphomaOnly 14 pages are availabe for public view
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Abstract
Background: Lymphoma comprises a histological heterogeneous group of cancers derived fromthe cells of the immune system manifested as enlargement and proliferation of lymph nodes orsecondary lymphoid tissues. Earlier, the imaging evaluation and follow-up of non-Hodgkin’slymphoma patients were based solely on findings at contrast-enhanced CT. Fortunately, 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography isgaining popularity for evaluating patients with non-Hodgkin lymphomas (NHLs) lymphoma andhas proven to be more sensitive and specific than contrast-enhanced CT for evaluating nodal andextra-nodal lymphomatous involvement.
Main body of abstract: 18 F-FDG PET/CT and the maximum standardized uptake value (SUVmax) is currently used for the diagnosis and initial staging of NHLs. The potential usefulness of(SUV max) in NHL cases and the significance of correlations between SUV max and variousindicators are currently unknown. The aim of the current study was to investigate whether the(SUV max) measured by 18 F-FDG PET/CT could discriminate between aggressive andindolent (NHLs) including different pathological subtypes and analyze the correlations between.the SUV max and other important parameters. A study was conducted among newly diagnosed60 adult NHL patients confirmed by biopsy, pretreatment 18F-FDG PET/CT scans, and acomplete medical record were retrospectively enrolled in the study including evaluation ofvarious clinical variables; clinical stage, pathological subtype, international Prognostic Index(IPI) score as well as lactate dehydrogenase (LDH) value and then correlated with SUV max ofthe biopsy site on PET/CT. The area under the ROC curve for examining the accuracy of SUVmax regarding distinguishing between aggressive and indolent NHLs was 0.85 and a cutoff valueof > 7.7 yielded a sensitivity of 90 % and specificity of 73 %. The SUV max mean plus/minus S * D .Oaggressive NHL was significantly higher than that of the indolent NHL (P < 0.001) . The SUVmax of the biopsy site was strongly positively correlated with IPI score and clinical staging ( P =0.001), but it was not significantly correlated with LDH (P > 0.05)
Short Conclusion: 18F-FDG PET/CT may yield reliable measurements of tumor proliferation,and an SUV max > 7.7 suggesting that SUV max was a useful predictor of diagnosis and maydistinguish between aggressive and indolent newly diagnosed NHLs in adults, SUV maxcorrelates with IPI score and clinical staging. SUV max doesn’t correlate to LDH.