الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Vitiligo is an acquired pigmentary disorder of the skin and mucous membranes which manifests as white macules and patches due to selective loss of melanocytes. Etiological hypotheses of vitiligo include genetic, immunological, neural, cytotoxic, biochemical, oxidative stress and newer theories of melanocytorrhagy. There are several types of vitiligo which are usually diagnosed clinically and confirmed by using a Wood’s lamp. Several treatment options are available for vitiligo that aim to stop disease progression and/or to attain repigmentation. However, most of traditional treatments seem to be inadequate. Microneedling therapy is a minimal invasive technique that used in treatment of vitiligo either alone or in combination with NB-UVB or immunomodulators such as tacrolimus and 5FU. The application of MN device by dermapen creates micro-channels through the stratum corneum for transdermal medication delivery to help absorption of topical drugs enhancing the efficacy and reducing the amount of the treatment. Autologous PRP has been used in different fields of dermatology specifically in aesthetic field for skin rejuvenation, scars, hair loss and recently used in vitiligo treatment. Its beneficial effect of re-pigmentation is hypothesized to be due the presence of multiple growth factors that results in cellular proliferation and new matrix formation. Chemical trauma by TCA induces re-pigmentation by simply destroying the basement membrane inducing pigmentary incontinence, or an epidermal inflammatory response ranging from early tyrosine kinase induction to the late upregulation of growth factors and reversing koebner phenomenon. Topical Vit D3 has been used to treat psoriasis, vitiligo and other skin diseases. It regulates keratinocyte proliferation and differentiation, angiogenesis, immune regulation and apoptosis. The aim of the present study was to compare the efficacy and safety of combined MN with plasma gel, TCA and topical Vit D3 in the treatment of stable non segmental vitiligo.