الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Purpose: The present study aimed at determination of the serum lipocalin-2 concentration and its correlation with degrees of itch, psoriatic arthritis (PsA) and body mass index (BMI) in psoriatic patients. Also, to correlate between level of lipocalin-2 and Ps severity using the Psoriasis Area and Severity Index (PASI) score. Materials and methods : The current study is a case-control study of 45 patients with psoriasis vulgaris (22 male &23 female) and 45 healthy controls of matched age and sex . The study was conducted on Egyptian patients attending the outpatient clinic of Dermatology Department, Mansoura University Hospitals. The study was conducted in the period from September, 2020 to September, 2021. . Serum LCN2 was measured and correlated with manifestations and severity of psoriasis. Results: : Psoriatic patients demonstrated a statistically significantly higher LCN2 concentration, in comparison with control group. There was a significantly higher LCN2 in psoriatic arthritis than in non-psoriatic arthritis. Conclusions High serum LCN2 concentrations in psoriatic patients are correlated with severity and particularly indicate disease activity. Keywords: Psoriasis, Lipocalin-2, Psoriasis Area and Severity Index (PASI) score.