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Abstract The development of cardiovascular disease is significantly impacted by insulin resistance (IR). In this regard, the triglyceride-glucose index (TyG index) serves as a reliable and efficient diagnostic tool for identifying IR. Previous research has indicated a potential predictive significance of the TyG index in individuals diagnosed with coronary artery disease. In this particular investigation, a cohort of 175 patients with diabetes who experienced ST-elevation myocardial infarction (STEMI) and underwent primary percutaneous coronary intervention (PCI) were included. The patients were classified into two distinct groups based on the presence or absence of major adverse cardiovascular and cerebral events (MACCEs) during the follow-up period, which spanned 30 days, 6 months, and 1 year. The TyG index was calculated by applying the natural logarithm to the ratio of fasting triglycerides to fasting phosphorus. A higher TyG index value was associated with an increased occurrence of Major Adverse Cardiovascular and Cerebrovascular Events (MACCEs) among patients with ST-Elevation Myocardial Infarction (STEMI) at 30 days, 6 months, and 1 year after undergoing Percutaneous Coronary Intervention (PCI). Regardless of other risk factors, there was a significant association between the TyG index and a higher occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with ST-elevation myocardial infarction (STEMI) within one year following their initial percutaneous coronary intervention (PCI) (p = 0.0001). Our study revealed that an elevated TyG index level was a robust and autonomous predictor of Major Adverse Cardiovascular and Cerebrovascular Events (MACCEs) in individuals with type 2 diabetes who underwent primary percutaneous coronary intervention (PCI) during a one-year timeframe. |