الفهرس 
Ventilator-associated pneumonia in neonatesOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Neonatal ventilator associated pneumonia (NVAP) is a major hospital- acquired infection in acute care settings, associated with high mortality and poor outcome. Myeloid cell trigger receptor-1 (TREM-1) is a member of the immunoglobulin super receptor family mainly expressed on the surface of myeloid cells such as neutrophils and monocytes/macrophages. Soluble TREM- 1 (sTREM-1), is a TREM-1 subtype that has been reported as a novel and strong indicator of pneumonia.
Aim and objectives: The Primary objective is to assess the value of sTREM-1as a diagnostic and a prognostic marker in NVAP and the Secondary Objective is to compare between sTREM-1 and CRP specificity and sensitivity.
Subjects and methods: This was a case-control study in the NICU at Children’s Hospital, Ain Shams University, Cairo, Egypt (6 months duration).this study was carried out on 50 cases devided into two groups each included 25 cases: group A: Ventilator associated pneumonia (VAP) in neonates (cases). group B: Age and sex matched neonates diagnosed with respiratory distress syndrome other than pneumonia and not ventilated (controls). The randomization was based on odd or even numbers of patient files number
Result: Regarding Day 1 sTREM-1, AUC was 0.942, Cutoff value was 112.55, Sensitivity was 92% and Specificity was 16%. Regarding Day 4 sTREM-1, AUC was 0.931, Cutoff value was 123.8, Sensitivity was 88% and Specificity was 80%.Regarding Day 1 CRP, AUC was 0.534, Cutoff value was 3.9, Sensitivity was 64% and Specificity was 44%. Regarding Day 4 CRP, AUC was 0.640, Cutoff value was 4.7, Sensitivity was 68% and Specificity was 40%.
Conclusion: sTREM-1 is as a diagnostic and prognostic indicator in ventilator-associated pneumonia for newborn. Comparison of sTREM-1 and C-reactive protein in terms of accuracy and sensitivity. STREM-1 has shown it to be more specific and sensitive than C-reactive protein (CRP).