الفهرس 
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Abstract
In patients with coronary artery disease (CAD), adiponectin mRNA expression was markedly decreased in epicardial adipose tissue (EAT), whereas multiple pro-inflammatory adipocytokines mRNA expression, including chemerin, IL-1β, IL-6 and TNF-α, were significantly increased. Thus, it is supposed that adipocytokines secreted by EAT via both paracrine and vasocrine mechanisms may regulate the process of atherosclerosis Omentin-1, is an adipokine, increases sensitivity to insulin, its decreased levels may be responsible for impaired glucose homeostasis. Omentin-1 inhibits TNF-induced inflammation of vascular smooth muscle cells, so its decreased levels in plasma of patients with CAD, indicated that omentin-1 may also be involved in the occurrence of ACS. Lower circulating omentin-1 levels associated with various metabolic risk factors, including elevated blood pressure, increased waist circumstance, dyslipidemia and glucose intolerance. In addition, serum omentin-1 levels were negatively associated with carotid plaque and positively correlated with cardiac autonomic neuropathy in patients with T2DM. Patients with CAD have also been observed to have lower circulating omentin-1 levels compared with those without CAD. Furthermore, it has been reported that serum omentin levels is a significant predictor of cardiovascular events in patients with suspected CAD and heart failure, as well as in hemodialysis patients with subclinical atherosclerosis. This study was designed to quantitative determination of human Omentin-1 by ELISA test in acute coronary syndrome with or without diabetes mellitus.