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Abstract The aim of this study is to make a comparison between anterior and lateral approaches of laparoscopic splenectomy including operative time, blood loss, operative complication, conversion to open surgery, postoperative complications and postoperative length of stay. It was a prospective randomized comparative study, conducted at general surgery department in Menoufia University hospitals, included 20 patients with splenic pathology indicated for surgery, patients were divided into two groups by closed envelope method: group 1 including 10 patients underwent laparoscopic splenectomy using anterior approach. group 2 including 10 patients underwent laparoscopic splenectomy using lateral approach. The duration of the study was 4 years Observational comparative checklist of the two groups were done based on the following criteria: Operative outcomes: operative time, blood loss, visceral or vascular injury, and conversion to open surgery Post-operative outcomes: post-operative hospital stay, bleeding and complications such as: chest infection, wound infection, pancreatic leak and acute gastric dilataion. Data collected was scored, tabulated and statistically analyzed. Summary 82 In group 1: Mean operative time of 149.5 ± 17.9 min. Mean blood loss was 98.5 ± 19.6 ml with conversion to open surgery in 2 patients 20 % of cases due to splenic injury. Post-operative complications were recorded in 2 patients (20%) of cases with a mean hospital stay of 3.1 ± 1.2 days. In group 2: Mean operative time of 131.7 ± 12.1 min. Mean blood loss was 190 ± 163 ml with conversion to open surgery in 1 patient 10 % of cases due to splenic injury. Post-operative complications were recorded in 2 patients (20%) of cases with a mean hospital stay of 2.7 ± 1 days. Our results showed that were statistically significant associations between type of procedure and both operative time and volume of blood loss. On the contrary, there was no statistically significant association between type of procedure and intraoperative complications or conversion to open surgery due to splenic injury or hospital stay or post-operative complications |