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العنوان
Using nuclear technique for estimation of some adipokine hormones level in obese rats as predictors of cardiovascular diseases and the possible therapeutic role of some promising medical herbs \
المؤلف
Shahin, Fathy Ameen Abdul-Hafiz.
هيئة الاعداد
باحث / فتحي أمين عبد الحفيظ شاهين
مشرف / مصطفى عبد الله محمد همام
مناقش / محمود محمد أحمد محمود
مناقش / مدحت مصطفى أبو زيد
الموضوع
Nuclear science and technology.
تاريخ النشر
2023.
عدد الصفحات
136 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الزراعية والبيولوجية
تاريخ الإجازة
10/12/2023
مكان الإجازة
جامعة المنوفية - كلية الزراعة - الكيمياء الحيوية الزراعية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Obesity raises the risk of cardiovascular disease via a variety of influencing factors, including hemodynamic changes, cardiac structure and function, inflammation, neurohumoral changes, and cellular remodelling. Major developing adipocytes may be linked to the production of leptin, angiotensin, proinflammatory cytokines, and reactive oxygen species. Furthermore, obesity is associated with increased inflammation, oxidative stress, and hyperleptinemia, all of which are linked to the development of cardiovascular disease and hypertension
Obesity is linked with elevated levels of triglycerides, cholesterol, and LDL (Low-Density Lipoprotein) cholesterol in the blood, as well as low levels of HDL (High-Density Lipoprotein) cholesterol . Obesity also is a significant predictor of high serum Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels .
Obesity develops primarily as a result of an imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by controlling cellular respiration and thermogenesis as well as identifying resting metabolic rate. Triiodothyronine affects lipid turnover in adipocytes and appetite regulation via the central nervous system, specifically the hypothalamus. TSH may also impact thermogenesis, suppress appetite, and regulate lipid storage via lipolysis and lipogenesis control .
Garlic (Allium sativum L.) was used as a pharmacological food for a long time. Garlic and its components were shown to have powerful regulatory activities in body processes such as blood clotting, lipid metabolism, immunity, and xenobiotic metabolism. In a rat model of high fat diet-induced obesity, garlic oil inhibited body weight gain and white adipose tissue mass .
Green tea contains catechins (such as epigallocatechin3-gallate) as well as quercetin, thearubigins, theaflavins, theanine, caffeine, chlorogenic acid, and gallic acid, which are derived from the leaves of Camellia sinensis . Green tea’s effect on obesity and body weight loss has been thoroughly researched in dietary studies
For the weight loss caused by green tea, several models have been suggested. These mechanisms include decreasing food intake, interfering with lipid emulsification and absorption, suppressing adipogenesis and lipid synthesis, and increasing energy expenditure through thermogenesis, fat oxidation, and fecal lipid