الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Administration of intensive lipid lowering therapy improved multiple plaque characteristics in non-culprit hemodynamically significant lesions with benefits gained as early as 3 months after ACS as assessed by IVUS NIRS, these beneficial effects included significant luminal gain and increasing minimal lumen area detected in scanned vessels.
PAV decreased significantly by a mean change of 1% in scanned vessels, lipidic content in non-culprit vessels, represented by maxLCBI4mm and plaque burden at minimal lumen area of scanned vessels decreased significantly with intensive lipid lowering therapy.
However, despite the changes in plaque composition with lipid lowering therapy, there were no significant changes in hemodynamic significance of scanned vessels, as proved with lack of changes in FFR over the study period.
Conclusions: -
Intensive lipid lowering therapy resulted in significant improvement of non-culprit plaque characteristics with early benefits obtained after 3 months, however these benefits weren’t translated into improvement of hemodynamic significance of these plaques.