الفهرس | Only 14 pages are availabe for public view |
Abstract Cancer is one of the leading causes of death. In modern medicine, chemotherapy, radiation therapy, and surgery are the main treatments accessible for cancer. Intervention with chemopreventive agents in the early stage of carcinogenesis is theoretically more rational than attempting to eradicate developed tumors with chemotherapeutic agents. These agents have a narrow margin of safety and also the therapy could fail because of drug resistance and dose-limiting toxicities, which can severely affect the host cells. hence the use of natural products is an alternate in the management and eradication of cancer. [1] Ehrlich tumor has been known as the Ehrlich cell which spread around research institutes all over the world. For three centuries, especially transplanted with chemical carcinogens and spontaneous tumor models have come fore in experimental cancer research. These models have been preferred frequently because they can be applied and also produced more easily in research centers. In the last 2–3 DCades, studies on cancer that can be transplanted have numerously increased. The Ehrlich tumor was initially described as a spontaneous murine mammary adenocarcinoma. It is a rapidly growing carcinoma with very aggressive behavior and can grow in almost all mice strains. It has been used as a transplantable tumor model to investigate the antineoplastic effects of several chemical compounds. After intraperitoneal inoculation of Ehrlich tumor cells, the ascitic volume and cells number increase drastically.[2] |