الفهرس 
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Abstract
Warts, or verrucae, are kind epithelial proliferations of skin and mucosa brought about by contamination with HPV. They are basic skin condition that can extend in seriousness from a minor disturbance that determines suddenly to troublesome, interminable condition.
No treatment works for all warts on all patients, but many options are available and, with time and patience, in immune-competent patients most warts (except periungual and subungual) will respond to treatment.
Few modalities have been created for the treatment of warts an all around powerful approach has not been investigated to date. Different ruinous and immunotherapeutic modalities have been utilized to treat warts. Every method of treatment has its own particular difficulties and disappointment rates.
Along these lines we outlined this work to think about the viability and safety of Candida antigen versus cryosurgery and the combination of both in the treatment of cutaneous warts.
This study was performed on 60 patients with common warts. The patients were divided into 3 equal groups, each containing 20 patients. In group (A) patients were directly injected with Candida antigen into the mother wart with a gradually increasing dose of 0.1 ml at the 1st session, 0.2 ml at the 2nd session and 0.3ml from the 3rd session till complete clearance or up to 5 sessions. Patients in group (B) got cryosurgery shower at 2 weeks interim until complete clearance or for a most extreme of five sessions. In group (C), patients were treated by a combination of intralesional injection of Candida antigen and cryosurgery until complete clearance of warts or for a maximum of five treatment sessions. Follow-up was made each month for 3 months to identify any repeat.
As regards therapeutic response, group (A) showed complete response in 5 patients (25%), moderate response in 4 patients (20%) and no response in 11 patients (55%). In group (B), complete clearance was observed in 8 patients (40%), marked response in 2 patients (10%), moderate response in 7 patients (35%) and no response in 3 patients (15%). While, in group (C), complete clearance was observed in 8 patients (40%), marked response in 4 patients (20%), moderate response in 8 patients (40%) and no response in none of the patients (0%). These results indicated that the combined therapy group (Candida antigen and cryosurgery) showed significantly higher efficacy as compared with candida antigen alone. No serious side effects were reported in any patient of the three studied groups. No recurrence was observed except in 4 patients of cryosurgery group, 2 patients in Candida antigen group, and 2 patients in the combined group.
In conclusion, cryosurgery combined with Candida antigen is a new effective therapy for multiple common warts. It is easy to apply, safe, of low cost, and higher efficacy in contrast to intralesional Candida antigen monotherapy. We highly recommend further studies to investigate and compare the results from different intralesional antigens immunotherapy if combined with cryosurgery or electrosurgery in the treatment of multiple common warts.