الفهرس | Only 14 pages are availabe for public view |
Abstract In fact, EC is a disease of the postmenopausal females, despite one fourth of the cases manifest in premenopausal females, with five percent occurring in cases aged <40 y. Average age of diagnosis is sixty . The majority of the risk factors of EC are related to unopposed endometrial stimulation by oestrogen for long duration . Infertility in addition to irregular menstrual cycles lead to anovulatory cycles and thus exposure to oestrogens with inadequate progesterone for long duration. Obesity leads to excess oestrone from peripheral aromatization of androstenedione as well. Other causes of prolonged oestrogen exposure include PCO, functioning ovarian neoplasm, exogenous menopausal oestrogen drugs without progestins elevate the risk. |