الفهرس | Only 14 pages are availabe for public view |
Abstract The present study contacted to evaluate molecular and biochemical effect of CAPE on DSS-induced ulcerative colitis in rats. Animals A 30 male albino rats weighing 150±10 g housed in plastic cages with stainless steel covers at the National Cancer Institute Animal House, Cairo University, Giza, Egypt. The animals were provided with standard diet and water ad libitum as well as kept for 2 weeks to acclimatize. Description of treatment groups Group1: Normal control which received 3 mL of distilled water, orally for 2 weeks. Group2: which received 10 mg/kg b.w. of Caffiec acid phenethyl ester orally in distilled water one dose for 2 weeks. Group3: Positive control which received 5% (w/v) Dextran sodium sulphate in drinking water, for 2 weeks. Group4: which received 5% (w/v) Dextran sodium sulphate in drinking water + Oral suspension of Caffiec acid phenethyl ester (10 mg/kg b.w.) in distilled water one dose for 2 weeks. Group5: which received 5% (w/v) ) Dextran sodium sulphate in drinking water + Oral suspension of Sulfasalazine (100 mg/kg.b.w.) in distilled water for 2 weeks. Determining of disease activity index (DAI) was measured degree of disease activity index (DAI) in experimental colitis. |