الفهرس | Only 14 pages are availabe for public view |
Abstract As the world’s population ages, Alzheimer’s disease (AD) is becoming more prevalent at an alarming rate [1]. AD exerts a significant impact on individuals directly affected by the condition, as well as on their caregivers and society as a whole in both advanced and developing nations. Due to its high rates of individual morbidity and mortality as well as its financial burden on the healthcare system, AD stands as one of the major healthcare hurdles of the current century [2-4]. AD the most prevalent form of dementia, is an age-related neurodegenerative disease that affects about 24 million people worldwide [5, 6]. By the end of 2030, the World Health Organization (WHO) predicts that this number will be increased by more than 100% [5]. Historically, AD is named after the German psychiatrist Alois Alzheimer [7]. When Alois Alzheimer examined the brain of his first patient, who experienced memory loss and a change in personality before passing away, he detected the presence of amyloid plaques and substantial neuronal decline. Consequently, he labeled this affliction as an exceedingly distressing disorder of the cerebral cortex |