الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Contrast-induced nephropathy is the third most common cause of in-hospital acute kidney injury (AKI). Although many different definitions have been used, the commonest definition of CI-AKI is an increase in serum creatinine (SCr) of >25% from baseline value or an absolute increase in SCr at 0.5 mg/dL, occurring within 48 to 72 hours following the intravascular administration of contrast media without an alternative explanation. (116) Known risk factors for CI-AKI include older age, diabetes mellitus, dehydration, hypotension, sepsis, cardiovascular disease, underlying AKI or chronic kidney disease, and concomitant use of nephrotoxic drugs. One risk factor that has gained increasing interest is serum uric acid (SUA). Hyperuricemia may be associated with an increased risk of contrast-induced acute kidney injury (CI-AKI). In recent years, studies about the relationship between them gradually appeared. (117) High SUA has also been reported to be an independent predictor for CI-AKI in some studies. However, not all studies showed an independent association between CI-AKI development and high baseline SUA levels. This study was designed to explore whether serum uric acid levels can predict the occurrence of contrast-induced nephropathy after elective percutaneous coronary intervention (PCI). This prospective study was conducted on 100 patients aged from 18 and 80 years who were candidates for elective PCI procedure. According to serum uric acid level on admission, patients were divided into 2 groups: • group A: patient with serum uric acid ≤ 7.0 mg/dL • group B: patient with serum uric acid > 7.0 mg/dL All patients were subjected to general and local examination, laboratory investigations including complete blood count (CBC), random blood sugar and kidney functions (Serum uric acid, serum urea, serum creatinine and creatinine clearance). Serum creatinine: will be measured 24, 48 and 72 hrs after the procedure. Also, resting 12 ECG, Resting Transthoracic Echocardiography (TTE) and coronary angiography were done for all participants.