الفهرس | Only 14 pages are availabe for public view |
Abstract The present study was undertaken to evaluate the impact of chrysanthemum on genotoxicity as well as renal & hepatic toxicity in the anticancer drug Capecitabine (xeloda) exposed male rats using comet assay and biochemical alterations. Thirty six male albino rat were divided into 6 groups (6 animals each) as follows:1) capecitabine (xeloda at dose of 30 mg as appositive control); 2) capecitabine (xeloda) + low dose of chrysanthemum (5 mg); 3) capecitabine (xeloda) + high dose of chrysanthemum (10 mg) ); 4) chrysanthemum (low dose, 5 mg) 5) chrysanthemum ( high dose, 10 mg); 6) Control group (negative control) for 45 days. The results of the present study revealed that capecitabine (xeloda) induced high frequency of DNA damage showed by alteration in tail length, tail moment, and DNA in tail. However, the treatment with Chrysanthemum significantly reduced the frequent of these parameters. The biochemical findings indicate that capecitabine (xeloda) treatment induce biochemical changes in hematological parameters, liver and kidney function, however the treatment with capecitabine (xeloda) in combination with Chrysanthemum ameliorate these changes especially with the high dose of Chrysanthemum. In conclusion, the data suggest that the complimentary use of Chrysanthemum with capecitabine (xeloda) treatment will be beneficial to reduce the adverse effect of capecitabine (xeloda) in chemotherapy, including the increased incidence of undesirable mutagenic and biochemical side effects. |