الفهرس 
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Abstract
Familial hypercholesterolemia (FH) is a world public health problem due to the high incidence of premature cardiovascular disease, mainly coronary artery disease. Early identification of persons with FH and their relatives, and the early start of treatment are very important issues in the prevention of premature cardiovascular disease and death among those populations.
Methods: The study included six hundred and ninety patients presented with STEMI. All patients presented with STEMI and were eligible for primary PCI within the first twenty four hours of chest pain at its maximum intensity were included. Patients were subjected to full history taking, physical examination, 12- lead ECG, coronary angiography and percutaneous intervention as indicated, as well as echocardiographic assessment and routine laboratory investigations. All studied patients were analyzed by Dutch Lipid Clinical Network (DLCN) criteria to detect FH.
In-hospital follow up including the incidence of major adverse cardiac events (MACE) defined as in-hospital mortality, cardiogenic shock, re-infarction, IRA revascularization (in-stent thrombosis), major bleeding, cerebrovascular accident and follow- up for recurrent chest pain, in hospital heart failure and arrhythmias was done.
Results: Of six hundred and ninety patients included in the final analysis, around three-quarters of patient scored 1 (n = 535). Further, nearly 9% (n = 61) scored 3. The rest of patients (0.9%, n = 6) scored 5. In the same way, the majority of cases (86%) were categorized by the DLCNS as unlikely FH (n = 594) and about 14% were categorized as possible/probable FH (n = 96). Patients with possible/probable FH were statistically significantly (P< 0.001) younger compared with those with unlikely FH. Similarly; there was statically significant relationship between the two groups regarding the KILLIP classification (P < 0.001). Multivariable regression model showed that both age and HTN were good predictors of possible/probable FH (P < 0.001, P = 0.044 respectively).
Conclusion: The majority of patients admitted for CAD didn’t had clinical criteria compatible with FH. FH as risk factor in STEMI patients who underwent PPCI represented small percentage around 14% of patients, young Age and HTN can be considered strong predictive factors in FH, so the early identification of FH risk of development of CVD.