الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Background:
Impaired intelligence, attention, memory and executive function is described in patients with chronic kidney disease (CKD) dialyzed and non-dialyzed, but we are still lacking the early and sensitive method of detection of these deficits. The purpose of the study is to test the correlation between the brain metabolic alteration (measured by MR spectroscopy) and cognitive dysfunction in CKD children (detected by psychometric analysis).
Subjects and methods:
We select 140 patients with CKD; 40 patients with stage 5 CKD on dialysis, 30 patients with stage 4 to 5 CKD without dialysis, 70 patients with stage 1 to 3 CKD. All patients with previous neurological disorders are excluded. Conventional MRI, MR spectroscopy and psychometric assessment by using Wechsler intelligence scale for children third edition were done for all subjects.
Results:
There was significant negative correlation between MRS abnormalities and Wechsler IQ test scores but there was positive significant correlation between the CKD stages and MRS abnormalities in patients with CKD and negative significant correlation between CKD stages and Wechsler IQ test scores in patients with CKD. There were correlations between ”the electrolyte disturbance, blood hemoglobin and hypertension” and ”the staging of CKD, cognitive functions IQ scores and MRS parameters changes”.
Conclusion:
We can concluded that; both MRS and psychometric tests are sensitive methods for detection of neurological and psychological affection in CKD children especially in dialyzed group and these findings appears before the clinical diagnosis.