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Abstract It has been established that Vitamin D hypovitaminosis can lead to decreased bone mineral density, hyperparathyroidism, rickets, osteoporosis, and increased risk of fracture. It has recently been suggested that deficiency is also associated with nonskeletal disorders such as hypertension, cardiovascular disease, diabetes, asthma, and cancer. It is possible that pediatric oncology patients are at risk for developing vitamin D deficiency in their treatment course due to poor nutrition, lack of sun exposure, and possible effects of treatment. Therefore, one could suggest that these children would have a higher prevalence of vitamin D hypovitaminosis than the general population. Although several studies have been done internationally on this topic none has been carried out thus far in an Egyptian population. The aim of this study was to find the frequency of Vitamin D insufficiency in children with cancer and once found to compare it with the frequency of the same among the healthy children of the same characteristics and explore any associations with age, sex, duration of therapy, and type of cancer. This cross-sectional, observational study included 28 patients who attended the pediatric oncology unit at Zagazig University Hospital in the period between January to September 2018. To fulfill the aim of this study a control group of 28 healthy children were recruited from schools and from the outpatient clinic presenting with minimal medical or surgical disorders with distributional matching to the patients on age and gender. Summary and conclusion 91 The population characteristics Children with different malignancies of both sexes aged below 15 years. Children are newly diagnosed cases with malignancy or on treatment whose Vitamin D levels were measured at least once during admission. We excluded any child receiving supplementation of vitamin D or those patients suffering from a disease that appeared due to Vitamin D deficiency. Also , we excluded children received therapy for a period longer than 2 years. Methodology Demographic data were collected from the subjects include age , sex, place & socioeconomic level. Age were recorded and categorized into two groups, those below 6 years and those above 6 years as seen in healthy chidren populations. Data concerning the tumor as type of cancer whether Leukemia/lymphoma or solid tumors, time of diagnosis to laboratory draw, , relapse status, and treatment status when the 25-OH D level was drawn as well as the duration of therapy were recorded as well. To fulfill the aim of this study a control group of 28 healthy children will be recruited from schools and from the outpatient clinic presenting with minimal medical or surgical disorders with distributional matching to the patients on age and gender. Approval for the study was obtained from our faculty Ethics Committee. Summary and conclusion 92 Assessment of Vitamin D levels 25-OH Vitamin D levels will be assessed by electro-chemiluminometric assay using Cobas 8000 (Roche). The cut-off value to define Vitamin D insufficiency is <30 ng/ml as decided by previous studies. The results of this study showed that: The prevalence of Vitamin D insufficiency in our study group (89.3%) while in the control group was 57.1% Vitamin D deficiency in the Leukemia and Lymphoma patients was 80% while in the solid tumors was 20 % and the percentage of normal vitamin D among Leukemia and Lymphoma was 66.7% while 33.3 % in solid tumor but there no significance correlation between solid and leukemia and lymphoma tumors according to vitamin D level. There was significance correlation between duration of chemotherapy and vitamin D deficiency level as the more duration of therapy the more increasing in vitamin D deficiency levels . The cut off value at which we can predict vitamin D level to start to become deficient is 3 months duration of chemotherapy. Summary and conclusion 93 Conclusion: This study provides preliminary evidence that the prevalence of vitamin D deficiency in a diverse Egyptian pediatric cancer population is higher than that of a comparable healthy population Among cancerous patients, children with hematological malignancies are more prone to Vit D deficiency than children with solid tumors. from our results it has been concluded that the more duration of therapy the more increasing in vitamin D deficiency levels . Vitamin D level start to becom |