الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The purpose of this study was to investigate the levels of Type I Collagen fragments ICTP (cross-linked carboxyterminal telopeptide of type I collagen) and CTX (C-terminal cross-linked telopeptide of type I collagen) in gingival crevicular fluid and saliva in the first leveling and alignment stage of orthodontic tooth movement. Fourteen adolescent patients [5 males, 9 females; age = 15.5 yrs (range = 13.1 – 17.6)] with moderate mandibular incisor crowding were fitted with preadjusted edgewise brackets and 0.014” nickel-titanium (Niti) wires. The main outcome measure was the levels of CTX and ICTP in the GCF and saliva. Samples were obtained from lower anterior teeth at 0, 1 d, 3 d, 7 d, 14 d, and 21 d after appliance placement. Enzyme-linked immunosorbent assay analysis (ELISA) was used to measure the levels of ICTP and CTX in the collected samples. The result found that the GCF and saliva ICTP and CTX levels did not significantly change between the time points (GCF ICTP P= 0.529, GCF CTX P= 0.581, saliva ICTP P= 0.023, saliva CTX P= 0.390). A statistically significant positive correlation and agreement was found between the levels of ICTP and CTX in saliva (P= 0.0001). However, there was no statistically significant correlation between the GCF and salivary levels of either ICTP or CTX or between ICTP and CTX levels in GCF. The CTX saliva level was not a statistically significant predictor of ICTP in saliva (p = 0.986).