الفهرس 
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Abstract
Immune thrombocytopenic purpura, an autoimmune disorder in which platelet count less than 100× 10⁹/L. It may be either acute or chronic.
A platelet count of less than 100× 10⁹/L is diagnostic of immune thrombocytopenic purpura, an autoimmune disorder that may cause bleeding complications. There is the potential for both sudden and long-term onset of symptoms.
The pathogenesis of ITP is quite complex. T cell immunological disorders are important contributors to the pathophysiology of ITP. The increased activation and proliferation of platelet auto-antigen-reactive CTLs, as well as the disruption of the Th1/Th2 balance, are characteristics of these T cell disorders.
NK cells are crucial in the development of autoimmune disorders.Target cell lysis and cytokine generation are their two main effector capabilities.
The purpose of this study was to evaluate the percentages of CD4+, CD8+, T helper cells, cytotoxic T cells and NK (CD16 +, CD56 +) cells in ITP patients in order to ascertain their contribution to the disease’s pathogenesis and whether or not this level was impacted by the pathology of the illness.
Investigations include peripheral blood samples from cases and controls were used to perform CBC, renal function tests , liver function tests, ESR, CD3,CD4,CD8,CD16,CD56, anti-nuclear antibody testing by immunofluorescence and bone marrow examinations only for cases.
This study we performed on 40 ITP patients diagnosed in Hematology unit in Clinical Pathology Department in Sohag University Hospital and 40 apparently healthy individuals.
This study demonstrated that there is no difference between acute and chronic ITP patients in terms of the T helper cell count when compared to control people.
Additionally, we discovered that there is no difference between acute and chronic ITP patients in the rise of cytotoxic T cells in ITP patients compared to controls.
NO difference in NK cells between ITP patients and control subjects and between patients with acute and chronic ITP.
Conclusion
This study’s conclusion listed some characteristics of immunological dysregulation found in ITP patients. When compared to the control group, these patients had lower CD4+, greater CD8+, lower T helper cells, and more cytotoxic T cells, but neither of these parameters could be used to predict the disease’s chronicity only.
Recommendation:
In view of the present study, we recommend the following:
To determine the percentages of CD4+, CD8+, T helper cells, cytotoxic T cells and NK cells in peripheral blood of ITP patients, more studies with bigger populations are strongly advised .
Follow up on cases following recovery and compare T helper cell, cytotoxic T cell and NK cell percentages between before and after the recovery.