![]() | Only 14 pages are availabe for public view |
Abstract Nephrotic syndrome (NS) is the most common glomerular disease seen in the pediatric age group. It is the second most common kidney disease seen in pediatric nephrology clinic, the most common being congenital malformations of the kidney and the urinary tract. It is characterized by massive proteinuria, hypoalbuminemia, peripheral edema and hyperlipidemia. Nephrotic syndrome in children is generally classified into steroid sensitive nephrotic syndrome (SSNS) and steroid resistant nephrotic syndrome (SRNS) based on the initial response to corticosteroid therapy at presentation. This classification resulted from the International Study of Kidney Disease in Children (ISKDC) studies in the 1970s,which showed that irrespective of morphological changes on kidney biopsy, the most important prognostic factor in NS is the response to corticosteroid and other immunosuppress. IL6-G/C rs1800795 is a SNP in the promoter of the interleukin- 6 IL6 gene, affecting the levels made of this important cytokine . It was first described in 1998, when it was shown thatthe rs1800795(C) allele produces less IL6 than the (G) alleleits role has been found in mesangial proliferative glomerulonephritis and endstage renal disease. The work aimed to find the relation between cytokine genes promoter polymorphisms (IL6G174C) and Nephrotic syndrome inchildren The present study conducted in nephrology and genetics units, pediatric department, Menoufia University Hospital on 90 children age range from 2 -18 years, period of the study from September 2020 to April 2022 Inclusion criteria: from 2-18 years Duration of disease > 2 months Both sexes Idiopathic nephrotic syndrome both (SSNS & SRNS) Exclusion criteria: Congenital or Secondary Nephrotic syndrome Syndromes and other auto immune disease. |