الفهرس 
Anatomical aspect of the cerebellumOnly 14 pages are availabe for public view
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Abstract
Autism affects multiple brain regions including the cerebellum.
Studies indicate that cerebellar dysfunction plays an important role in the
pathogenesis of autism.
VPA is a broad spectrum anti-epileptic drug well known as the
treatment of choice in wide range of seizure disorders. However, it is
associated with several side effects including congenital anomalies and
increased rate of autism in the offspring of epileptic mothers who are
treated with it during early pregnancy.
Many studies indicate that lycopene has a neuroprotective effect
due to its antioxidant, anti-inflammatory, cognitive enhancing and
neurotransmitter modulatory properties. So, it can reduce the oxidative
damage, neuroinflammation and neuronal toxicity produced by VPA, and
thus protect against neurodegeneration.
The present study was performed to study the possible
neuroprotective and therapeutic effects of lycopene on the cerebellum in
valproic acid induced rat model of autism; biochemically and
histologically.