الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
CKD is characterised by the occurrence of both GFR < 60 mL/min as well as urinary albumin exceeding 30 mg/g creatinine along with disrupted kidney function or structure for a duration exceeding 3 months.
ESRD or chronic renal failure is the terminal CKD stage and is identified by a decreased GFR of < 15 mL/min. In Egypt, ESRD is one of the major medical issues. The estimated incidence of ESRD in Egypt is 74 PMP per year, and the overall prevalence of patients on dialysis is 264 PMP. ESRD has a great burden on health and socioeconomic status in Egypt as well as worldwide. In Egypt, Hypertension comes as the primary cause of ESRD followed by DM.
CVD is a well-recognized drawback in HD patients and is the main etiology of mortality in them. ESRD patients have a twenty-fold increase in mortality over the general population due to adverse CV outcomes.
MiR-155 is a typical miR with multiple functions. It is involved in multiple biological processes such as hematopoiesis, immunity, inflammation, viral infection, malignancy, as well as CVD.
The present work aimed to study the serum level of miR-155 as a probable biomarker of adverse CV outcomes in Egyptian patients with ESRD.
To achieve this goal, 45 male subjects who gave written informed consent were involved in our study, and divided into the following groups:
group I: included 15 ESRD male patients on maintenance HD suffering from CV complications.