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العنوان
Post -transplantation Cyclophosphamide as Graft Versus Host Disease prophylaxis in Children with β-Thalassemia Major undergoing Hematopoietic Stem Cell Transplantation
المؤلف
El-Naggar, Eman Mohammed Fath Allah.
هيئة الاعداد
باحث / ايمان محمد فتح اللة النجار
مشرف / محمد رمضان الشنشورىى
مشرف / ناهد محمد حبلص
مشرف / جمال الدين محمد فتحى
الموضوع
Pediatric
تاريخ النشر
2024.
عدد الصفحات
p. : 227
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
20/3/2024
مكان الإجازة
جامعة طنطا - كلية الطب - طب الاطفال
الفهرس
Only 14 pages are availabe for public view

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Abstract

.β-thalassemias are a group of recessively inherited hemoglobin disorders characterized by reduced synthesis of β globin chains. Thalassemia constitutes the most common inherited recessive disorder associated with consanguinity, which is a common phenomenon in Egypt. Allo-HSCT is the only established treatment modality that provides a possibility of cure and
considered cost effective compared with conventional therapy. Current
results of transplantation in pediatrics from matched related donors offer
80% to 87% probability of cure according to risk classes. The thalassemia
free survival was respectively 85–90% for class I, 80% for class II, and 70%
for class III, while the TRM increased from class I to III.